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Chemotherapy initiation with single-course methotrexate alone or combined with dactinomycin versus multi-course

Frontiers of Medicine 2022, Volume 16, Issue 2,   Pages 276-284 doi: 10.1007/s11684-021-0855-4

Abstract: Patients were allocated to three initiated regimens: single-course methotrexate (MTX), single-courseMTX+ dactinomycin (ACTD), and multi-course MTX (control arm).The primary CR rate was 64.4% with multi-course MTX in the control arm.For the single-course MTX arm, the CR rate was 35.8% by one course; it increased to 59.3% after subsequentFor the single-course MTX+ACTD arm, the CR rate was 46.7% by one course, which increased to 89.1% after

Keywords： gestational trophoblastic neoplasia (GTN)     methotrexate (MTX)     dactinomycin (ACTD)    

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New perspective on the natural course of chronic HBV infection

Yong-Yuan Zhang,Ke-Qin Hu,Zhongping Duan

Frontiers of Medicine 2014, Volume 8, Issue 2,   Pages 129-134 doi: 10.1007/s11684-014-0339-x

Abstract: A better understanding of the natural course of chronic HBV infection may shed new light on the mechanismsNatural course of chronic HBV infection is conventionally viewed as an uninterrupted process that isHowever, none of these descriptions captures or highlights the core events that determine the natural courseand reinfection, and such cycles prolong the chronic HBV infection course.Reviewing published data on the natural course of chronic HBV infection can reduce the possibility of

Keywords： hepatitis B virus     chronic HBV infection     natural course     hepatitis B     seroconversion    

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The Origin of Traditional Chinese Medicine and Thinking on Chinese Medicine Development

Wang Wenkui,Wang Feng,Wang Ling

Strategic Study of CAE 2006, Volume 8, Issue 4,   Pages 1-11

Abstract: fame of outstanding advantage in curative effect, it seems that the TCM is not quite adaptable to the development

Keywords： traditional Chinese medicine (TCM)     development course & status of TCM     adopting the advanced part of    

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Breaking the Silos of Discipline for Integrated Student Learning: A Global STEM Course’s CurriculumDevelopment

Katherine Shirey

Engineering 2018, Volume 4, Issue 2,   Pages 170-174 doi: 10.1016/j.eng.2018.03.006

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An Algorithm of Evacuation Time Which Simulates the Evacuation Course

Zhu Jiaying,Zhang Heping

Strategic Study of CAE 2006, Volume 8, Issue 8,   Pages 73-76

Abstract: paper, the evacuation facilities such as doors were abstracted as units of the net, and the evacuation course

Keywords： evacuation arithmetic     room unit     series-wound model     shunt-wound model    

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核能发展国际高端论坛 International Summit on Nuclear Energy Development

Conference Date: 15 May 2019

Conference Place: 中国

Administered by: 中国工程院

核能发展国际高端论坛 International Summit on Nuclear Energy Development

Conference Date: 15 May 2019

Conference Place: 中国

Administered by: 中国工程院

Optoelectronic Crystals, All-Solid-State Lasers and their Applications——An Important Course of Optoelectronics

Xu Zuyan

Strategic Study of CAE 1999, Volume 1, Issue 2,   Pages 72-77

Abstract:

The age of optoelectronics is the consequence of rapid evolution and mutual integration of the fields of micro-electronics, laser technology and material science. The appearance of optical fibers and laser diodes in the 1960s, one major contribution of optoelectronic technology to information industry, has led to the advent of optoelectronic communications. In the 1990s, great advances in optoelectronic crystals and breakthroughs in laser diode technology have made all-solid-state lasers a practical realization. As a consequence, this will enable optoelectronics to make its further contribution to more national pillar industries in the first half of the next century, in various aspects like material processing in advanced manufacturing, optical storage in information technology, laser displays in entertainment, laser fusion power station, nuclear fission material processing, upgrading of laser weapons, etc.

Keywords： optoelectronic crystals     all-solid-state lasers     material processing     optical storage     laser displays     laser fusion    

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Innovative development path of ethnomedicines: the interpretation of the path

Zhaoyun Zhu,Dehuan Fu,Yali Gui,Tao Cui,Jingkun Wang,Ting Wang,Zhizhong Yang,Yanfei Niu,Zhennan She,Li Wang

Frontiers of Medicine 2017, Volume 11, Issue 1,   Pages 32-47 doi: 10.1007/s11684-016-0495-2

Abstract:

One of the primary purposes of the innovative development of ethnomedicines is to use their excellentThe innovative development path of ethnomedicines includes the following three primary stages: resourcestudy, standardized development research, and industrialization of the achievements and efforts forThe implementation of this path is always guaranteed by the research and development platform and thepath of ethnomedicines to provide useful references for the development of proper ethnomedicine use.

Keywords： ethnomedicines     innovative development path     resource study     standardized development research     industrialization    

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Application of Grading of Recommendations Assessment, Development, and Evaluation (GRADE) to the guidelinedevelopment for clinical practice with acupuncture and moxibustion

Hong Zhao, Fengxia Liang, Yigong Fang, Baoyan Liu

Frontiers of Medicine 2017, Volume 11, Issue 4,   Pages 590-594 doi: 10.1007/s11684-017-0537-4

Abstract:

Grading of Recommendations Assessment, Development, and Evaluation (GRADE) offers a worldwide approachto guideline development for clinical practice.In this study, we review the advantages and limitations of the GRADE approach in the guideline developmentThe limitations of GRADE in the development of guidelines for acupuncture and moxibustion include ratingIn the guideline development for clinical practice with acupuncture and moxibustion, we suggest that

Keywords： guideline     acupuncture     GRADE    

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Lean Product Development—Faster, Better … Cleaner?

Geert Letens

Frontiers of Engineering Management 2015, Volume 2, Issue 1,   Pages 52-59 doi: 10.15302/J-FEM-2015007

Abstract: To address this challenge, lean product development has emerged to become the leading improvement methodologyWhile lean product development has its origin in the best practice studies of Japanese car manufacturersThe primary purpose of this work is to untangle the fuzziness that still surrounds lean product developmentand to ground the key aspects of lean product development based on insights from six studies publishedThis demonstrates how better and faster product development can be achieved through the integration of

Keywords： lean product development     sustainability engineering     responsible design    

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The development and benefits of metformin in various diseases

Frontiers of Medicine 2023, Volume 17, Issue 3,   Pages 388-431 doi: 10.1007/s11684-023-0998-6

Abstract: Metformin has been used for the treatment of type II diabetes mellitus for decades due to its safety, low cost, and outstanding hypoglycemic effect clinically. The mechanisms underlying these benefits are complex and still not fully understood. Inhibition of mitochondrial respiratory-chain complex I is the most described downstream mechanism of metformin, leading to reduced ATP production and activation of AMP-activated protein kinase (AMPK). Meanwhile, many novel targets of metformin have been gradually discovered. In recent years, multiple pre-clinical and clinical studies are committed to extend the indications of metformin in addition to diabetes. Herein, we summarized the benefits of metformin in four types of diseases, including metabolic associated diseases, cancer, aging and age-related diseases, neurological disorders. We comprehensively discussed the pharmacokinetic properties and the mechanisms of action, treatment strategies, the clinical application, the potential risk of metformin in various diseases. This review provides a brief summary of the benefits and concerns of metformin, aiming to interest scientists to consider and explore the common and specific mechanisms and guiding for the further research. Although there have been countless studies of metformin, longitudinal research in each field is still much warranted.

Keywords： metformin     metabolism     cancer     aging     neurological disorder    

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Strategic position and development prospects of nuclear energy in China

SHEN Wenquan

Frontiers in Energy 2007, Volume 1, Issue 2,   Pages 125-128 doi: 10.1007/s11708-007-0015-9

Abstract: By analyzing the challenges of China s energy supply, an excellent perspective of nuclear power developmentTaking into account the near-, mid-, and long-term development requirements, a comprehensive, coordinated

Keywords： development     excellent perspective     long-term development     comprehensive     national    

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SUSTAINABLE DEVELOPMENT OF CROP-LIVESTOCK FARMS IN AFRICA

Frontiers of Agricultural Science and Engineering 2021, Volume 8, Issue 1,

Abstract: required to meet to this demand, and (3) the opportunities to integrate broader societal goals into the developmentThere is ample room for development of crop-livestock farms in Africa, and keeping integration as partof the development will help prevent many of the mistakes and environmental problems related to theThis development can integrate biodiversity, climate change adaptation and mitigation to the current
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Increasing significance of advanced physical/chemical processes in the development and application of

RULKENS Wim

Frontiers of Environmental Science & Engineering 2008, Volume 2, Issue 4,   Pages 385-396 doi: 10.1007/s11783-008-0073-1

Abstract: Development of more environmentally sustainable wastewater treatment chains in which physical/chemical

Keywords： control     beneficial     valuable     scarcity     Development    

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Title Author Date Type Operation

Chemotherapy initiation with single-course methotrexate alone or combined with dactinomycin versus multi-course

Journal Article

New perspective on the natural course of chronic HBV infection

Yong-Yuan Zhang,Ke-Qin Hu,Zhongping Duan

Journal Article

The Origin of Traditional Chinese Medicine and Thinking on Chinese Medicine Development

Wang Wenkui,Wang Feng,Wang Ling

Journal Article

Breaking the Silos of Discipline for Integrated Student Learning: A Global STEM Course’s CurriculumDevelopment

Katherine Shirey

Journal Article

An Algorithm of Evacuation Time Which Simulates the Evacuation Course

Zhu Jiaying,Zhang Heping

Journal Article

核能发展国际高端论坛 International Summit on Nuclear Energy Development

15 May 2019

Conference Information

核能发展国际高端论坛 International Summit on Nuclear Energy Development

15 May 2019

Conference Information

Optoelectronic Crystals, All-Solid-State Lasers and their Applications——An Important Course of Optoelectronics

Xu Zuyan

Journal Article

Innovative development path of ethnomedicines: the interpretation of the path

Zhaoyun Zhu,Dehuan Fu,Yali Gui,Tao Cui,Jingkun Wang,Ting Wang,Zhizhong Yang,Yanfei Niu,Zhennan She,Li Wang

Journal Article

Application of Grading of Recommendations Assessment, Development, and Evaluation (GRADE) to the guidelinedevelopment for clinical practice with acupuncture and moxibustion

Hong Zhao, Fengxia Liang, Yigong Fang, Baoyan Liu

Journal Article

Lean Product Development—Faster, Better … Cleaner?

Geert Letens

Journal Article

The development and benefits of metformin in various diseases

Journal Article

Strategic position and development prospects of nuclear energy in China

SHEN Wenquan

Journal Article

SUSTAINABLE DEVELOPMENT OF CROP-LIVESTOCK FARMS IN AFRICA

Journal Article

Increasing significance of advanced physical/chemical processes in the development and application of

RULKENS Wim

Journal Article